The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)

BACKGROUND: Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute to the initiation and progression of breast cancer determining pro-tumorigenic...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Lappano, Rosamaria, Talia, Marianna, Cirillo, Francesca, Rigiracciolo, Damiano Cosimo, Scordamaglia, Domenica, Guzzi, Rita, Miglietta, Anna Maria, De Francesco, Ernestina Marianna, Belfiore, Antonino, Sims, Andrew H., Maggiolini, Marcello
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418191/
https://ncbi.nlm.nih.gov/pubmed/32778144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01667-y
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