Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic link can be exploited for therapeutic purposes with orally active chemical chaperones. 4-Phenyl butyric acid and taurine-conjugated ursodeoxycholi...

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Udgivet i:Science
Main Authors: Özcan, Umut, Yilmaz, Erkan, Özcan, Lale, Furuhashi, Masato, Vaillancourt, Eric, Smith, Ross O., Görgün, Cem Z., Hotamisligil, Gökhan S.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741373/
https://ncbi.nlm.nih.gov/pubmed/16931765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1128294
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