Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

Obesity and metabolic diseases appear as clusters, often featuring high risk for insulin resistance and type 2 diabetes, and constitute a major global health problem with limited treatment options. Previous studies have shown that double-stranded RNA–dependent kinase, PKR, plays an important role in...

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Autori principali: Nakamura, Takahisa, Arduini, Alessandro, Baccaro, Brenna, Furuhashi, Masato, Hotamisligil, Gökhan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900541/
https://ncbi.nlm.nih.gov/pubmed/24150608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1019
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