Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α‐mediated stress signaling

Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular stresses. The serine–threonine protein phosphatase 1 (PP1) d...

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Vydáno v:EMBO J
Hlavní autoři: Santos, Celio XC, Hafstad, Anne D, Beretta, Matteo, Zhang, Min, Molenaar, Chris, Kopec, Jola, Fotinou, Dina, Murray, Thomas V, Cobb, Andrew M, Martin, Daniel, Zeh Silva, Maira, Anilkumar, Narayana, Schröder, Katrin, Shanahan, Catherine M, Brewer, Alison C, Brandes, Ralf P, Blanc, Eric, Parsons, Maddy, Belousov, Vsevelod, Cammack, Richard, Hider, Robert C, Steiner, Roberto A, Shah, Ajay M
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741303/
https://ncbi.nlm.nih.gov/pubmed/26742780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592394
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