Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α‐mediated stress signaling

Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular stresses. The serine–threonine protein phosphatase 1 (PP1) d...

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Publicado no:EMBO J
Main Authors: Santos, Celio XC, Hafstad, Anne D, Beretta, Matteo, Zhang, Min, Molenaar, Chris, Kopec, Jola, Fotinou, Dina, Murray, Thomas V, Cobb, Andrew M, Martin, Daniel, Zeh Silva, Maira, Anilkumar, Narayana, Schröder, Katrin, Shanahan, Catherine M, Brewer, Alison C, Brandes, Ralf P, Blanc, Eric, Parsons, Maddy, Belousov, Vsevelod, Cammack, Richard, Hider, Robert C, Steiner, Roberto A, Shah, Ajay M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741303/
https://ncbi.nlm.nih.gov/pubmed/26742780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592394
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