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Serum-based culture conditions provoke gene expression variability in mouse embryonic stem cells as revealed by single cell analysis

Variation in gene expression is an important feature of mouse embryonic stem cells (ESCs). However, the mechanisms responsible for global gene expression variation in ESCs are not fully understood. We performed single cell mRNA-seq analysis of mouse ESCs and uncovered significant heterogeneity in ES...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Guo, Guoji, Pinello, Luca, Han, Xiaoping, Lai, Shujing, Shen, Li, Lin, Ta-Wei, Zou, Keyong, Yuan, Guo-Cheng, Orkin, Stuart H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740311/
https://ncbi.nlm.nih.gov/pubmed/26804902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.089
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