Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

Strategies to prevent diabetic microvascular angiopathy focus on the vascular endothelium. Because red blood cells (RBCs) are less deformable in diabetes, we explored an original concept linking decreased RBC deformability to RBC ascorbate and hyperglycemia. We characterized ascorbate concentrations...

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Publicat a:EBioMedicine
Autors principals: Tu, Hongbin, Li, Hongyan, Wang, Yu, Niyyati, Mahtab, Wang, Yaohui, Leshin, Jonathan, Levine, Mark
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740302/
https://ncbi.nlm.nih.gov/pubmed/26870799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.09.049
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