Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

Strategies to prevent diabetic microvascular angiopathy focus on the vascular endothelium. Because red blood cells (RBCs) are less deformable in diabetes, we explored an original concept linking decreased RBC deformability to RBC ascorbate and hyperglycemia. We characterized ascorbate concentrations...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Tu, Hongbin, Li, Hongyan, Wang, Yu, Niyyati, Mahtab, Wang, Yaohui, Leshin, Jonathan, Levine, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740302/
https://ncbi.nlm.nih.gov/pubmed/26870799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.09.049
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