Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo

Despite its transport by glucose transporters (GLUTs) in vitro, it is unknown whether dehydroascorbic acid (oxidized vitamin C, DHA) has any in vivo function. To investigate, we created a chemical transport knockout model using the vitamin C analog 6-bromo-ascorbate. This analog is transported on so...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Tu, Hongbin, Wang, Yu, Li, Hongyan, Brinster, Lauren R., Levine, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605377/
https://ncbi.nlm.nih.gov/pubmed/28851583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.08.017
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