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Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

Strategies to prevent diabetic microvascular angiopathy focus on the vascular endothelium. Because red blood cells (RBCs) are less deformable in diabetes, we explored an original concept linking decreased RBC deformability to RBC ascorbate and hyperglycemia. We characterized ascorbate concentrations...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: Tu, Hongbin, Li, Hongyan, Wang, Yu, Niyyati, Mahtab, Wang, Yaohui, Leshin, Jonathan, Levine, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740302/
https://ncbi.nlm.nih.gov/pubmed/26870799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.09.049
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