Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

Transferrin receptor (Tfr1) is ubiquitously expressed, but its roles in non-hematopoietic cells are incompletely understood. We used a tissue-specific conditional knockout strategy to ask whether skeletal muscle required Tfr1 for iron uptake. We found that iron assimilation via Tfr1 was critical for...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Barrientos, Tomasa, Laothamatas, Indira, Koves, Timothy R., Soderblom, Erik J., Bryan, Miles, Moseley, M. Arthur, Muoio, Deborah M., Andrews, Nancy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740293/
https://ncbi.nlm.nih.gov/pubmed/26870796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.09.041
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