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A vocabulary of ancient peptides at the origin of folded proteins

The seemingly limitless diversity of proteins in nature arose from only a few thousand domain prototypes, but the origin of these themselves has remained unclear. We are pursuing the hypothesis that they arose by fusion and accretion from an ancestral set of peptides active as co-factors in RNA-depe...

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Veröffentlicht in:eLife
Hauptverfasser: Alva, Vikram, Söding, Johannes, Lupas, Andrei N
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739770/
https://ncbi.nlm.nih.gov/pubmed/26653858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09410
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