Structural basis of death domain signaling in the p75 neurotrophin receptor

Death domains (DDs) mediate assembly of oligomeric complexes for activation of downstream signaling pathways through incompletely understood mechanisms. Here we report structures of complexes formed by the DD of p75 neurotrophin receptor (p75(NTR)) with RhoGDI, for activation of the RhoA pathway, wi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Lin, Zhi, Tann, Jason Y, Goh, Eddy TH, Kelly, Claire, Lim, Kim Buay, Gao, Jian Fang, Ibanez, Carlos F
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2015
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739766/
https://ncbi.nlm.nih.gov/pubmed/26646181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11692
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