Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

Articular cartilage has poor capability for repair following trauma or degenerative pathology due to avascular property, low cell density and migratory ability. Discovery of novel therapeutic approaches for articular cartilage repair remains a significant clinical need. Hypoxia is a hallmark for car...

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Veröffentlicht in:PLoS One
Hauptverfasser: Wang, Pengzhen, Zhang, Fengjie, He, Qiling, Wang, Jianqi, Shiu, Hoi Ting, Shu, Yinglan, Tsang, Wing Pui, Liang, Shuang, Zhao, Kai, Wan, Chao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739592/
https://ncbi.nlm.nih.gov/pubmed/26841115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148372
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