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Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ
Recent work has highlighted roles for JAK (Janus kinase) family members in haemopoietic diseases. Although sequencing efforts have uncovered transforming JAK1 mutations in acute leukaemia, they have also identified non-transforming JAK1 mutations. Thus with limited knowledge of the mechanisms of JAK...
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| Udgivet i: | Biochem J |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4739517/ https://ncbi.nlm.nih.gov/pubmed/20868368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100774 |
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