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FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma

Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by...

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Autors principals: Elliott, Natalina E., Cleveland, Susan M., Grann, Victor, Janik, John, Waldmann, Thomas A., Davé, Utpal P.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193267/
https://ncbi.nlm.nih.gov/pubmed/21821710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-319467
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