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Mutations in the Transmembrane and Juxtamembrane Domains Enhance IL27R Transforming Activity

Cytokines and their receptors regulate hematopoiesis by controlling cellular growth, survival, and differentiation. Thus, it is not surprising that mutations of cytokine receptors contribute to the formation of hematopoietic disorders including cancer. We recently identified transforming properties...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lambert, Que T., Pradhan, Anuradha, Roll, J. Devon, Reuther, Gary W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145822/
https://ncbi.nlm.nih.gov/pubmed/21631431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110351
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