Efficient Synthesis of Chiral Trisubstituted 1,2‐Allenyl Ketones by Catalytic Asymmetric Conjugate Addition of Malonic Esters to Enynes

An N,N′‐dioxide/scandium(III) complex catalyzed, highly efficient conjugate addition of malonic esters to enynes is described. A range of trisubstituted 1,2‐allenyl ketones were obtained in high yields (up to 99 %) with good d.r. (up to 95/5) and excellent ee values (97 %–99 %). Moreover, the produc...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Yao, Qian, Liao, Yuting, Lin, Lili, Lin, Xiaobin, Ji, Jie, Liu, Xiaohua, Feng, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738401/
https://ncbi.nlm.nih.gov/pubmed/26694204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509455
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