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Taking a Measured Approach to Toxicity Data in Phase I Oncology Clinical Trials

The standard categorical system for assessing attribution of toxicity to study drug(s) in phase I trials is cumbersome and uninformative. While a binary system (‘related’ versus ‘unrelated’) would be sufficient to define maximum tolerated dose, a probability estimation would better support dose sele...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Sharma, Manish R., Ratain, Mark J.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738103/
https://ncbi.nlm.nih.gov/pubmed/26467385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2005
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