The IL-15-based ALT-803 complex enhances FcγRIIIa-triggered NK cell responses and in vivo clearance of B cell lymphomas

PURPOSE: Anti-CD20 monoclonal antibodies (mAbs) are an important immunotherapy for B cell lymphoma, and provide evidence that the immune system may be harnessed as an effective lymphoma treatment approach. ALT-803 is a super-agonist IL-15 mutant and IL-15Rα–Fc fusion complex that activates the IL-15...

詳細記述

保存先:
書誌詳細
出版年:Clin Cancer Res
主要な著者: Rosario, Maximillian, Bai, Liu, Kong, Lin, Collins, Lynne I., Schneider, Stephanie E., Chen, Xiaoyue, Han, Kaiping, Jeng, Emily K., Rhode, Peter R., Leong, Jeffrey W., Schappe, Timothy, Jewell, Brea A., Keppel, Catherine R., Shah, Keval, Hess, Brian, Romee, Rizwan, Piwnica-Worms, David R., Cashen, Amanda F., Bartlett, Nancy L., Wong, Hing C., Fehniger, Todd A.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738096/
https://ncbi.nlm.nih.gov/pubmed/26423796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1419
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