The IL-15-based ALT-803 complex enhances FcγRIIIa-triggered NK cell responses and in vivo clearance of B cell lymphomas

PURPOSE: Anti-CD20 monoclonal antibodies (mAbs) are an important immunotherapy for B cell lymphoma, and provide evidence that the immune system may be harnessed as an effective lymphoma treatment approach. ALT-803 is a super-agonist IL-15 mutant and IL-15Rα–Fc fusion complex that activates the IL-15...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Rosario, Maximillian, Bai, Liu, Kong, Lin, Collins, Lynne I., Schneider, Stephanie E., Chen, Xiaoyue, Han, Kaiping, Jeng, Emily K., Rhode, Peter R., Leong, Jeffrey W., Schappe, Timothy, Jewell, Brea A., Keppel, Catherine R., Shah, Keval, Hess, Brian, Romee, Rizwan, Piwnica-Worms, David R., Cashen, Amanda F., Bartlett, Nancy L., Wong, Hing C., Fehniger, Todd A.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738096/
https://ncbi.nlm.nih.gov/pubmed/26423796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1419
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