Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage

The ubiquitously expressed β2-spectrin (β2SP, SPTBN1) is the most common non-erythrocytic member of the β-spectrin gene family. Loss of β2-spectrin leads to defects in liver development, and its haploinsufficiency spontaneously leads to chronic liver disease and the eventual development of hepatocel...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Baek, Hye Jung, Lee, Yong Min, Kim, Tae Hyun, Kim, Joo-Young, Park, Eun Jung, Iwabuchi, Kuniyoshi, Mishra, Lopa, Kim, Sang Soo
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737674/
https://ncbi.nlm.nih.gov/pubmed/26884715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.13420
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