TGF-β signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: Role of the β-spectrin, ELF

We have shown that loss of ELF, a stem cell adaptor protein, disrupts TGF-β signaling through Smad3 and Smad4 localization. Notably elf(+)(/)(−)/smad4(+)(/)(−) mice develop gastric cancer presenting this as an important model for analyzing molecular event in gastric carcinogenesis. To gain further i...

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Autori principali: Kim, Sang Soo, Shetty, Kirti, Katuri, Varalakshmi, Kitisin, Krit, Baek, Hye Jung, Tang, Yi, Marshall, Blair, Johnson, Lynt, Mishra, Bibhuti, Mishra, Lopa
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211257/
https://ncbi.nlm.nih.gov/pubmed/16650383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.03.236
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