Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation

Transforming growth factor-β (TGF-β) signaling members, TGF-β receptor type II (TBRII), Smad2, Smad4 and Smad adaptor, embryonic liver fodrin (ELF), are prominent tumor suppressors in gastrointestinal cancers. Here, we show that 40% of elf(+/−) mice spontaneously develop hepatocellular cancer (HCC)...

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Detalhes bibliográficos
Main Authors: Kitisin, K, Ganesan, N, Tang, Y, Jogunoori, W, Volpe, EA, Kim, SS, Katuri, V, Kallakury, B, Pishvaian, M, Albanese, C, Mendelson, J, Zasloff, M, Rashid, A, Fishbein, T, Evans, SRT, Sidawy, A, Reddy, EP, Mishra, B, Johnson, LB, Shetty, K, Mishra, L
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211268/
https://ncbi.nlm.nih.gov/pubmed/17546056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210513
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