Epigenetic Silencing of β-Spectrin, a TGF-β Signaling/Scaffolding Protein in a Human Cancer Stem Cell Disorder: BECKWITH-WIEDEMANN SYNDROME

Hereditary cancer syndromes provide powerful insights into dysfunctional signaling pathways that lead to sporadic cancers. Beckwith-Wiedemann syndrome (BWS) is a hereditary human cancer stem cell syndrome currently linked to deregulated imprinting at chromosome 11p15 and uniparental disomy. However,...

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Main Authors: Yao, Zhi-Xing, Jogunoori, Wilma, Choufani, Sanaa, Rashid, Asif, Blake, Tiffany, Yao, Wenguo, Kreishman, Peter, Amin, Rupen, Sidawy, Anton A., Evans, Stephen R. T., Finegold, Milton, Reddy, E. Premkumar, Mishra, Bibhuti, Weksberg, Rosanna, Kumar, Rakesh, Mishra, Lopa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975233/
https://ncbi.nlm.nih.gov/pubmed/20739274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162347
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