Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease

Inhibition of the cysteine protease cruzain from Trypanosoma cruzi has been studied pre-clinically as a new chemotherapeutic approach to treat Chagas’ Disease. Efficacious effects of vinylsulfone-based cruzain inhibitors in animal models support this therapeutic hypothesis. More recently, substrate-...

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Neitz, R. Jeffrey, Bryant, Clifford, Chen, Steven, Gut, Jiri, Caselli, Estefania Hugo, Ponce, Servando, Chowdhury, Somenath, Xu, Haichao, Arkin, Michelle R., Ellman, Jonathan A., Renslo, Adam R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737481/
https://ncbi.nlm.nih.gov/pubmed/26144347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.066
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