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H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility
Histone H2AX becomes phosphorylated in chromatin domains flanking sites of DNA double-strand break-age associated with γ-irradiation, meiotic recombination, DNA replication, and antigen receptor rearrangements. Here, we show that loss of a single H2AX allele compromises genomic integrity and enhance...
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| Gepubliceerd in: | Cell |
|---|---|
| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4737479/ https://ncbi.nlm.nih.gov/pubmed/12914701 |
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