AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another. This enables a single variable (V) region gene to be used in conjunction with different downstream Ch genes, each having a unique biol...

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Pubblicato in:Nature
Autori principali: Petersen, Simone, Casellas, Rafael, Reina-San-Martin, Bernardo, Chen, Hua Tang, Difilippantonio, Michael J., Wilson, Patrick C., Hanitsch, Leif, Celeste, Arkady, Muramatsuk, Masamichi, Pilch, Duane R., Redon, Christophe, Ried, Thomas, Bonner, William M., Honjo, Tasuku, Nussenzweig, Michel C., Nussenzweig, André
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729367/
https://ncbi.nlm.nih.gov/pubmed/11740565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/414660a
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