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AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another. This enables a single variable (V) region gene to be used in conjunction with different downstream Ch genes, each having a unique biol...
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Veröffentlicht in: | Nature |
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Hauptverfasser: | , , , , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
2001
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4729367/ https://ncbi.nlm.nih.gov/pubmed/11740565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/414660a |
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