AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another. This enables a single variable (V) region gene to be used in conjunction with different downstream Ch genes, each having a unique biol...

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Publicado no:Nature
Main Authors: Petersen, Simone, Casellas, Rafael, Reina-San-Martin, Bernardo, Chen, Hua Tang, Difilippantonio, Michael J., Wilson, Patrick C., Hanitsch, Leif, Celeste, Arkady, Muramatsuk, Masamichi, Pilch, Duane R., Redon, Christophe, Ried, Thomas, Bonner, William M., Honjo, Tasuku, Nussenzweig, Michel C., Nussenzweig, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729367/
https://ncbi.nlm.nih.gov/pubmed/11740565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/414660a
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