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Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1
Mre11, Rad50, and Nbs1 form an evolutionarily conserved protein complex (Mre11–Rad50–Nbs1, MRN) that has been proposed to function as a DNA damage sensor. Hypomorphic mutations in Mre11 and Nbs1 result in the human ataxia–telangiectasia-like disorder and Nijmegen breakage syndrome (NBS), respectivel...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC547831/ https://ncbi.nlm.nih.gov/pubmed/15668392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406289102 |
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