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H2AX regulates meiotic telomere clustering

The histone H2A variant H2AX is phosphorylated in response to DNA double-strand breaks originating from diverse origins, including dysfunctional telomeres. Here, we show that normal mitotic telomere maintenance does not require H2AX. Moreover, H2AX is dispensable for the chromosome fusions arising f...

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Détails bibliographiques
Auteurs principaux: Fernandez-Capetillo, Oscar, Liebe, Bodo, Scherthan, Harry, Nussenzweig, André
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173436/
https://ncbi.nlm.nih.gov/pubmed/14530383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200305124
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