H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

Histone H2AX becomes phosphorylated in chromatin domains flanking sites of DNA double-strand break-age associated with γ-irradiation, meiotic recombination, DNA replication, and antigen receptor rearrangements. Here, we show that loss of a single H2AX allele compromises genomic integrity and enhance...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Celeste, Arkady, Difilippantonio, Simone, Difilippantonio, Michael J., Fernandez-Capetillo, Oscar, Pilch, Duane R., Sedelnikova, Olga A., Eckhaus, Michael, Ried, Thomas, Bonner, William M., Nussenzweig, André
Format: Artigo
Langue:Inglês
Publié: 2003
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737479/
https://ncbi.nlm.nih.gov/pubmed/12914701
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