Species‐specific action of (Pro3)GIP – a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

BACKGROUND AND PURPOSE: Specific, high potency receptor antagonists are valuable tools when evaluating animal and human physiology. Within the glucose‐dependent, insulinotropic polypeptide (GIP) system, considerable attention has been given to the presumed GIP receptor antagonist, (Pro3)GIP, and its...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Sparre‐Ulrich, A H, Hansen, L S, Svendsen, B, Christensen, M, Knop, F K, Hartmann, B, Holst, J J, Rosenkilde, M M
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737396/
https://ncbi.nlm.nih.gov/pubmed/26359804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13323
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