Species‐specific action of (Pro3)GIP – a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

BACKGROUND AND PURPOSE: Specific, high potency receptor antagonists are valuable tools when evaluating animal and human physiology. Within the glucose‐dependent, insulinotropic polypeptide (GIP) system, considerable attention has been given to the presumed GIP receptor antagonist, (Pro3)GIP, and its...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Sparre‐Ulrich, A H, Hansen, L S, Svendsen, B, Christensen, M, Knop, F K, Hartmann, B, Holst, J J, Rosenkilde, M M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737396/
https://ncbi.nlm.nih.gov/pubmed/26359804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13323
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