N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor

BACKGROUND AND PURPOSE: Glucose‐dependent insulinotropic polypeptide (GIP) affects lipid, bone and glucose homeostasis. High‐affinity ligands for the GIP receptor are needed to elucidate the physiological functions and pharmacological potential of GIP in vivo. GIP(1–30)NH(2) is a naturally occurring...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Hansen, L S, Sparre‐Ulrich, A H, Christensen, M, Knop, F K, Hartmann, B, Holst, J J, Rosenkilde, M M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761099/
https://ncbi.nlm.nih.gov/pubmed/26572091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13384
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