N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor

BACKGROUND AND PURPOSE: Glucose‐dependent insulinotropic polypeptide (GIP) affects lipid, bone and glucose homeostasis. High‐affinity ligands for the GIP receptor are needed to elucidate the physiological functions and pharmacological potential of GIP in vivo. GIP(1–30)NH(2) is a naturally occurring...

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Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Hansen, L S, Sparre‐Ulrich, A H, Christensen, M, Knop, F K, Hartmann, B, Holst, J J, Rosenkilde, M M
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761099/
https://ncbi.nlm.nih.gov/pubmed/26572091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13384
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