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An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring. We have proposed that desertomycin A and similar compounds (marginolactones) are formed by polyketide synthases primed not with γ‐aminobutanoyl‐CoA but with 4‐guanidinylbutanoyl‐CoA, to avoid facile cyclization of the starte...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4737276/ https://ncbi.nlm.nih.gov/pubmed/26630438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509300 |
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