LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner

Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To determine mechanisms underlying growth promotion by LRH-1 in CRC, we undertook global expression profiling following siRNA-mediated LRH-1...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Kramer, Holly B., Lai, Chun-Fui, Patel, Hetal, Periyasamy, Manikandan, Lin, Meng-Lay, Feller, Stephan M., Fuller-Pace, Frances V., Meek, David W., Ali, Simak, Buluwela, Laki
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737183/
https://ncbi.nlm.nih.gov/pubmed/26400164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv948
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