Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

Orphan nuclear receptor Small Heterodimer Partner (SHP; NR0B2) is a transcriptional corepressor of a wide variety of nuclear receptors (NRs). Here, we report that SHP recruits SIRT1, a class III histone deacetylase, in an NR-specific manner to inhibit transcriptional activity. SHP interacts and co-l...

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Hlavní autoři: Chanda, Dipanjan, Xie, Yuan-Bin, Choi, Hueng-Sik
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919721/
https://ncbi.nlm.nih.gov/pubmed/20375098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq227
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