Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis

Doxorubicin (DOX) is a widely used antineoplastic drug whose efficacy is limited by its cardiotoxicity. The aim of this study was to investigate the possible protective role of the antidiabetic drugs metformin (250 mg/kg dissolved in DW p.o. for seven days) and sitagliptin (10 mg/kg dissolved in DW...

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Vydáno v:J Toxicol
Hlavní autoři: Kelleni, Mina Thabet, Amin, Entesar Farghaly, Abdelrahman, Aly Mohamed
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736207/
https://ncbi.nlm.nih.gov/pubmed/26880912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/424813
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