The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms

BACKGROUND: Dual specificity phosphatases are a class of tumor-associated proteins involved in the negative regulation of the MAP kinase pathway. Downregulation of the dual specificity phosphatase 2 (DUSP2) has been reported in cancer. Epigenetic silencing of tumor suppressor genes by abnormal promo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Cancer
Main Authors: Haag, Tanja, Richter, Antje M., Schneider, Martin B., Jiménez, Adriana P., Dammann, Reinhard H.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736155/
https://ncbi.nlm.nih.gov/pubmed/26833217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2087-6
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