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S phase block following MEC1(ATR) inactivation occurs without severe dNTP depletion
Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhibitor of ribonucleotide reductase (RNR), causing a...
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| Publié dans: | Biol Open |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4736042/ https://ncbi.nlm.nih.gov/pubmed/26603472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.015347 |
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