S phase block following MEC1(ATR) inactivation occurs without severe dNTP depletion

Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhibitor of ribonucleotide reductase (RNR), causing a...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Biol Open
Huvudupphovsmän: Earp, Caroline, Rowbotham, Samuel, Merényi, Gábor, Chabes, Andrei, Cha, Rita S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Company of Biologists 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736042/
https://ncbi.nlm.nih.gov/pubmed/26603472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.015347
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk