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Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
The molecular mechanisms underlying the ability of axons to regenerate after injury remain poorly understood. Here we show that in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible transcription factor...
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| Izdano u: | Nat Commun |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735912/ https://ncbi.nlm.nih.gov/pubmed/26790951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10388 |
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