Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

The molecular mechanisms underlying the ability of axons to regenerate after injury remain poorly understood. Here we show that in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible transcription factor...

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Foilsithe in:Nat Commun
Main Authors: Alam, Tanimul, Maruyama, Hiroki, Li, Chun, Pastuhov, Strahil Iv., Nix, Paola, Bastiani, Michael, Hisamoto, Naoki, Matsumoto, Kunihiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735912/
https://ncbi.nlm.nih.gov/pubmed/26790951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10388
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