Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity

OBJECTIVE: As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed. We have recently shown that obesity is associated with reactivated liver Notch signaling, which, in turn, increases hepatic in...

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Vydáno v:Mol Metab
Hlavní autoři: Sparling, David P., Yu, Junjie, Kim, KyeongJin, Zhu, Changyu, Brachs, Sebastian, Birkenfeld, Andreas L., Pajvani, Utpal B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735659/
https://ncbi.nlm.nih.gov/pubmed/26909319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.11.006
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