Gamma-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor

Excess plasma triglycerides (TG) are a key component of obesity-induced metabolic syndrome. We have shown that γ-secretase inhibitor (GSI) treatment improves glucose tolerance due to inhibition of hepatic Notch signaling, but find additional, Notch-independent reduction of plasma TG-rich lipoprotein...

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Publicat a:Cell Metab
Autors principals: Kim, KyeongJin, Goldberg, Ira J., Graham, Mark J., Sundaram, Meenakshi, Bertaggia, Enrico, Lee, Samuel, Qiang, Li, Haeusler, Rebecca A., Metzger, Daniel, Chambon, Pierre, Yao, Zemin, Ginsberg, Henry N., Pajvani, Utpal B.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884729/
https://ncbi.nlm.nih.gov/pubmed/29576536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.02.010
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