mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors

CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) play critical roles in controlling the processes of tumors, infections, autoimmunity and graft rejection. Immunosuppressive drug rapamycin (RPM), targeting on the key cellular metabolism molecule mTOR, is currently used in clinics to treat pat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Wu, Tingting, Zhao, Yang, Wang, Hao, Li, yang, Shao, Lijuan, Wang, Ruoyu, Lu, Jun, Yang, Zhongzhou, Wang, Junjie, Zhao, Yong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735296/
https://ncbi.nlm.nih.gov/pubmed/26833095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20250
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