mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors

CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) play critical roles in controlling the processes of tumors, infections, autoimmunity and graft rejection. Immunosuppressive drug rapamycin (RPM), targeting on the key cellular metabolism molecule mTOR, is currently used in clinics to treat pat...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Wu, Tingting, Zhao, Yang, Wang, Hao, Li, yang, Shao, Lijuan, Wang, Ruoyu, Lu, Jun, Yang, Zhongzhou, Wang, Junjie, Zhao, Yong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735296/
https://ncbi.nlm.nih.gov/pubmed/26833095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20250
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