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mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors
CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) play critical roles in controlling the processes of tumors, infections, autoimmunity and graft rejection. Immunosuppressive drug rapamycin (RPM), targeting on the key cellular metabolism molecule mTOR, is currently used in clinics to treat pat...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735296/ https://ncbi.nlm.nih.gov/pubmed/26833095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20250 |
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