mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors

CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) play critical roles in controlling the processes of tumors, infections, autoimmunity and graft rejection. Immunosuppressive drug rapamycin (RPM), targeting on the key cellular metabolism molecule mTOR, is currently used in clinics to treat pat...

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Udgivet i:Sci Rep
Main Authors: Wu, Tingting, Zhao, Yang, Wang, Hao, Li, yang, Shao, Lijuan, Wang, Ruoyu, Lu, Jun, Yang, Zhongzhou, Wang, Junjie, Zhao, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735296/
https://ncbi.nlm.nih.gov/pubmed/26833095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20250
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