The mTOR Deficiency in Monocytic Myeloid-Derived Suppressor Cells Protects Mouse Cardiac Allografts by Inducing Allograft Tolerance

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) can prevent allograft rejection and induce immune tolerance in transplantation models. Previous studies have demonstrated that inhibition of mTOR signaling can enhance the MDSC protective effect in heart transplantation (HTx) by promoting MDSC exp...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Li, Jiawei, Chen, Juntao, Zhang, Mingnan, Zhang, Chao, Wu, Renyan, Yang, Tianying, Qiu, Yue, Liu, Jingjing, Zhu, Tongyu, Zhang, Yi, Rong, Ruiming
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062712/
https://ncbi.nlm.nih.gov/pubmed/33897705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.661338
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