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The mTOR Deficiency in Monocytic Myeloid-Derived Suppressor Cells Protects Mouse Cardiac Allografts by Inducing Allograft Tolerance

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) can prevent allograft rejection and induce immune tolerance in transplantation models. Previous studies have demonstrated that inhibition of mTOR signaling can enhance the MDSC protective effect in heart transplantation (HTx) by promoting MDSC exp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Li, Jiawei, Chen, Juntao, Zhang, Mingnan, Zhang, Chao, Wu, Renyan, Yang, Tianying, Qiu, Yue, Liu, Jingjing, Zhu, Tongyu, Zhang, Yi, Rong, Ruiming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062712/
https://ncbi.nlm.nih.gov/pubmed/33897705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.661338
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